Spermidine is a natural polyamine that has been shown to have various health benefits. Here’s what we know about spermidine from the latest peer-reviewed articles:
Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases
- Spermidine has been shown to modulate aging, suppress the occurrence and severity of age-related diseases, and prolong lifespan[1].
- The precise mechanisms of how spermidine works are still being studied[1].
Spermidine Delays Aging in Humans
- Epidemiological evidence suggests that increased uptake of spermidine with food reduces overall, cardiovascular, and cancer-related mortality in humans[2].
- High spermidine uptake is an independent favorable prognostic parameter for reduced mortality, meaning that this variable predicts a reduced incidence of death even after correction for possible confounding factors such as age, body mass index, consumption of alcohol or aspirin, diabetes, metabolic syndrome, physical activity, sex, socioeconomic status, and even dietary quality[2].
- Spermidine has been classified as a “caloric restriction mimetic” that has broad health-promoting effects due to its capacity to induce similar biochemical changes as does caloric restriction[2].
Dietary Spermidine Improves Cognitive Function
- Recent studies have revealed health-protective and lifespan-extending effects of dietary spermidine, a natural autophagy-promoting polyamine[4].
- Spermidine has been shown to improve cognitive function[4].
Serum Spermidine in Relation to Risk of Stroke
- In humans, a high dietary spermidine intake correlates with reduced blood pressure, which is an important protective factor of stroke[5].
Mechanisms of Spermidine-Induced Autophagy and Geroprotection
- Spermidine supplementation preserves telomere length in aging mice[6].
- The exact mechanism of how spermidine works is yet to be revealed and could be due to anti-ROS[6].
Overall, spermidine has been shown to have various health benefits, including delaying aging, improving cognitive function, and reducing the risk of stroke. While the precise mechanisms of how spermidine works are still being studied, it is clear that spermidine has broad health-promoting effects and is a promising candidate for clinical evaluation.